At a glance
ob体育 is working to compile the most up to date guidance and information for front-line healthcare professionals to consult when treating and preventing Lyme Disease in patients. Check out the resources below for more information.
Ordering Information for Educational Materials
Resource
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Tools for the clinic
Lyme disease prophylaxis after tick bite
Note: In general, ob体育 does not recommend antibiotics after tick bites to prevent tickborne diseases. However, in certain circumstances, a single dose of doxycycline after a tick bite in an area where Lyme disease is common may lower risk of Lyme disease.
Lyme disease serologic testing and pretest probability
A patient’s pretest probability for Lyme disease helps inform whether they should be tested for Lyme disease.
Evaluation of pediatric knee monoarthritis in areas where Lyme disease occurs
Note: This tool is intended to support healthcare providers. Providers should use clinical judgement, taking into account the patient's history, diagnostic testing, and prior treatment when making clinical decisions for their patients.
Special thanks to Pedi Lyme Net and Dr. Lise Nigrovic for their research and input on the flow chart.
APHL guidance and interpretation of Lyme disease serologic test results
These tools describe the proper interpretation of serologic testing for B. burgdorferi and identify best practices for reporting results to clinicians, public health agencies, and patients.
Additional reading
General
Halperin JJ, Baker P, Wormser GP. Am J Med 2013;126(3):264.
Hu LT. . Ann Intern Med. 2016 May 3;164(9).
Kugeler KJ, Schwartz AM, Delorey MJ, et al. . Emerg Infect Dis. 2021 Feb;27(2):616-619.
Schwartz AM, Kugeler KJ, Nelson CA, et al. . Emerg Infect Dis. 2021;27(2):499-507.
Stanek G, Wormser GP, Gray J, Strle F. Lancet 2012;379(9814):461-73.
Lyme carditis
Marx GE, Leikauskas J, Lindstrom K, et al. Annals of Internal Medicine 2020;172(3): 222-224.
Forrester JD, Mead P. Clin Infect Dis 2014 May 30. pii: ciu411.
Lyme disease post-exposure prophylaxis after tick bite
Nadelman RB, et al. N Engl J Med. 2001 Jul 12;345(2):79-84.
Harms MG, et al. J Infect. 2021 Jan;82(1):98-104.
Pediatrics and pregnancy
American Academy of Pediatrics. In: Pickering LK, Red Book: 2021.
Grant DS, Neville DN, Levas M, et al. . Pediatr Emerg Care. 2021 May 13.
Sood SK. . Infect Dis Clin North Am. 2015 Jun;29(2):281-94.
Waddell LA, Greig J, Lindsay LR, et al. . PLoS One. 2018 Nov 12;13(11):e0207067.
Testing
Aguero-Rosenfeld ME, Wang G, Schwartz I, Wormser GP. Clin Microbiol Rev 2005 Jul;18(3):484-509.
Association of Public Health Laboratories. 2021.
Branda JA, Steere AC. . Clin Microbiol Rev. 2021 Jan 27;34(2):e00018-19.
Branda JA, Strle F, Strle K, Sikand N, Ferraro MJ, Steere AC. Clin Infect Dis 2013 Aug;57(3):333-40.
Concerns regarding a new culture method for Borrelia burgdorferi not approved for the diagnosis of Lyme disease. MMWR 2014;63:333.
Hinckley AF, Connally NP, Meek JI, et al. Clin Infect Dis 2014 May 30. pii: ciu397.
Johnson BJ, Pilgard MA, Russell TM. J Clin Microbiol 2014;52:721–4.
Johnson, B.J. "Chapter 4: Laboratory diagnostic testing for Borrelia burgdorferi infection" in Lyme disease: An Evidence-based Approach, J.J. Halperin, Ed. (CAB International, 2011). Complete Article Reproduced with Permission. [PDF – 16 pages]
Mead P, Petersen J, Hinckley A. Updated ob体育 recommendation for serologic diagnosis of Lyme disease. MMWR Morb Mortal Wkly Rep. 2019 Aug 16;68(32):703.
Moore A, Nelson C, Molins C, et al. . Emerg Infect Dis. 2016 Jul;22(7).
Notice to readers: caution regarding testing for Lyme disease. MMWR, ob体育 Surveillance Summary 2005;54:125.
Recommendations for test performance and interpretation from the second national conference on serologic diagnosis of Lyme disease. MMWR 1995;44:590–591.
Swanson SJ, Neitzel D, Reed KD, Belongia EA. Clin Microbiol Rev 2006 Oct;19(4):708-27.
Ongoing research
Check out for studies of Lyme disease and Borrelia Infections.
Biomedical Literature
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