About
Outcome data on infants born to women with hepatitis B virus (HBV) infection are collected, analyzed, and reported by 64 jurisdictions to the ob体育 Perinatal Hepatitis B Prevention Program (PHBPP).1 Persons with chronic HBV infection serve as the main reservoir for HBV transmission, therefore, preventing HBV infection is important. Chronic infection occurs among 80%–90% of persons infected during infancy. Approximately 25% of persons who become chronically infected during childhood will die prematurely from cirrhosis or liver cancer.1 The ob体育 PHBPP1 funds 64 jurisdictions to identify pregnant women with HBV infection and manage the health care of their infants to improve receipt of post-exposure prophylaxis (PEP) (hepatitis B vaccine birth dose and hepatitis B immune globulin), hepatitis B vaccine series completion, and post-vaccination serologic testing to prevent mother-to-child HBV transmission.
Locations
Participating jurisdictions are the 50 United States, District of Columbia, five cities (Chicago, Houston, New York City, Philadelphia, and San Antonio), five territories (American Samoa, Guam, N. Mariana Islands, Puerto Rico, and US Virgin Islands), and three freely associated island nations (Federated States of Micronesia, Republic of the Marshall Islands, and Republic of Palau).
What's collected
Data in this report are from the reporting period for the 2022 birth cohort, followed from January 1, 2022–December 31, 2023, and only includes infants whose care was managed by the PHBPP.
Follow-up time for infants varies in length depending on their date of birth. Jurisdictions follow enrolled infants through completion of post-vaccination serologic testing. In general, infants are followed through 12–24 months of age. Because of differences in how data are reported through the PHBPP (reported using birth year) and ob体育 National Notifiable Diseases Surveillance System (NNDSS) (reported using diagnosis or event date), there may be differences in the number of cases reported through these two systems.
- 1. Koneru A, Fenlon N, Schillie S, et al. . Pediatrics March 2021;147(3) e20201823.