Very Low Nicotine Content Cigarettes

At a glance

Most people who smoke want to quit. Nicotine is an addictive substance in cigarettes and other tobacco products. Cigarettes with very low nicotine levels may help people smoke less or quit. Quitting smoking completely is very important to protect health.

The bottom line

  • Nicotine is highly addictive and plays a dominant role in sustaining commercial tobacco use.
  • Using any commercial tobacco product is unsafe. Quitting smoking is very important to protect health.
  • Lowering nicotine to minimally addictive or nonaddictive levels in all cigarettes would help prevent people from smoking regularly and could also help people quit smoking.
  • Preventing and stopping tobacco use would reduce tobacco-related disease and death.

Very low nicotine content cigarettes

Nicotine is a highly addictive chemical found in tobacco products.12 Nicotine can harm the developing adolescent brain.23 It can lead to lifelong nicotine addiction and plays a dominant role in sustaining commercial tobacco use.

Cigarette companies have intentionally adjusted nicotine levels in cigarettes to promote addiction. These adjustments cause people to become addicted to cigarettes and keep smoking.4

Very low nicotine content cigarettes are cigarettes with nicotine levels so low they are minimally addictive or are not addictive.5

The public health impact of very low nicotine content cigarettes

Studies show that people who smoke cigarettes and switch to very low nicotine content cigarettes reduce the number of cigarettes they smoke each day.678 However, only reducing the number of cigarettes smoked each day, rather than quitting cigarettes completely, can still lead to serious health problems. Very low nicotine content cigarettes are still harmful. Quitting completely is the best way to protect health.92

Studies show that many people who smoke cigarettes and switch to very low nicotine content cigarettes try to quit smoking, and many are successful.10111213

Studies have found there is support for reducing nicotine in cigarettes to minimally addictive or nonaddictive levels, including among adults who smoke and those who want to quit.14151617

Very low nicotine content cigarettes could be more effective at helping people quit if all cigarettes on the market had very low levels of nicotine.17 In addition, research suggests that if all cigarettes on the market had very low levels of nicotine, they may be even more effective at helping people quit if there were no menthol-flavored low-nicotine cigarettes.17

In 2022, the U.S. Food and Drug Administration (FDA) announced it would develop a proposed rule establishing a maximum nicotine content level in cigarettes and certain other combusted tobacco products, to make those products less addictive.18

Reducing the nicotine in cigarettes to minimally addictive or nonaddictive levels could help prevent people who experiment with cigarettes from becoming dependent on nicotine and transitioning to regular use. Reducing the nicotine levels in cigarettes to minimally addictive or nonaddictive levels also could help people quit smoking. This strategy should be even more effective when combined with public education campaigns that explain the reasons for the policy and when proven smoking cessation treatments—behavioral counseling and FDA-approved medications—are provided to help people quit.192017 Helping people quit using tobacco products completely offers the best protection from tobacco-related death and disease.

  1. Apelberg BJ, Feirman SP, Salazar E, et al. . N Engl J Med. 2018;378(18):1725–1733.
  2. U.S. Dept of Health and Human Services. The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. U.S. Dept of Health and Human Services, Centers for Disease Control and Prevention; 2014. Accessed July 18, 2024.
  3. U.S. Food and Drug Administration. Tobacco Product Standard for Nicotine Level of Combusted Cigarettes. 83 Fed. Reg. 11,818. March 16, 2018. Accessed July 18, 2024.
  4. United States v. Philip Morris USA, Inc. 449 F.Supp.2d 1 (D.D.C. 2006). Accessed July 18, 2024.
  5. Benowitz NL, Henningfield JE. . N Engl J Med. 1994 Jul 14;331(2):123–125.
  6. Puljevic C, Feulner L, Hobbs M, et al. . Tob Control. 2023:tc-2022-057715.
  7. Puljevic C, Morphett K, Hefler M, et al. . Tob Control. 2022;31:365–375.
  8. Shiffman S, Kurland BF, Scholl SM, Mao JM. JAMA Psychiatry 2018;75(10):995–1002.
  9. U.S. Dept of Health and Human Services. Smoking Cessation: A Report of the Surgeon General. U.S. Dept of Health and Human Services, Centers for Disease Control and Prevention; 2020. Accessed July 18, 2024.
  10. Donny EC, Denlinger RL, Tidey JW, et al. . N Engl J Med. 2015;373(14):1340–1349.
  11. Foulds J, Veldheer S, Pachas G, et al. . PLoS One. 2022;17(11):e0275522.
  12. Hatsukami DK, Kotlyar M, Hertsgaard LA, et al. . Addiction. 2010;105(2):343–355.
  13. Higgins ST, Tidey JW, Sigmon SC, et al. JAMA Netw Open. 2020;3(10):e2019311.
  14. Ali FRM, Al-Shawaf M, Wang TW, King BA. Am J Prev Med. 2019;57(3):403–407.
  15. Denlinger-Apte RL, Koopmeiners JS, Tidey JW, et al. . Addict Behav. 2021;114:106727.
  16. Fairman RT, Cho YJ, Popova L, et al. . Tob Control. 2023:tc-2023-058128.
  17. U.S. Dept of Health and Human Services. Eliminating Tobacco-Related Disease and Death: Addressing Disparities—A Report of the Surgeon General. U.S. Dept of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2024.
  18. U.S. Food and Drug Administration. FDA news release: FDA announces plans for proposed rule to reduce addictiveness of cigarettes and other combusted tobacco products. Updated June 21, 2022. Accessed July 18, 2024.
  19. Benowitz NL, Nardone N, Dains KM, et al. . Addiction. 2015;110(10):1667–1675.
  20. Hatsukami DK, Donny EC, Koopmeiners JS, Benowitz NL. . Cancer Epidemiol Biomarkers Prev. 2015;24(2):472–476.