Predicting Pneumococcus Resistance to β-lactam Antibiotics

Minimum Inhibitory Concentrations Predicted by Penicillin Binding Protein Types

Key points

  • ob体育's Streptococcus Laboratory created procedures to predict phenotypic susceptibility results for multiple antibiotics using whole-genome sequencing data.
  • For beta (β)-lactam antibiotics, the procedure uses penicillin binding protein (PBP) types.

Overview

PBP types are based on transpeptidase-encoding regions of PBP proteins 1a, 2b, and 2x.

Laboratory personnel can use a machine-learning algorithm to predict a specific level of resistance based on a S. pneumoniae isolate's PBP gene type1234.

Reference resources

Streptococcus pneumoniae pipeline

PBP type sequence databases

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Content Source:
National Center for Immunization and Respiratory Diseases; Division of Bacterial Diseases
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