Key points
- This page summarizes publications related to Tdap vaccination during pregnancy and related topics.
- Review the following list of publications to learn more about preventing whooping cough (pertussis) in newborns.

General
Abu-Raya B, Forsyth K, Halperin SA, et al. . Vaccines (Basel). 2022;10(12):1990.
Halperin BA, Halperin SA. Future Microbiol. 2011;6(4):367–9.
Libster R, Edwards KM. Clin Infect Dis. 2012;54(1):85–7.
McIntyre PB, Clark TA. Lancet. 2014;384(9953):1484–6.
Mooi FR, de Greeff SC. . Lancet Infect Dis. 2007;7(9):614–24.
Munoz FM. . Womens Health (Lond Engl). 2007;3(2):227–41.
Tanaka M, Vitek CR, Pascual FB, Bisgard KM, Tate JE, Murphy TV. . JAMA. 2003;290(22):2968–75.
Effectiveness and impact
Amirthalingam G, Andrews N, Campbell H, et al. . Lancet. 2014;384(9953):1521–28.
Baxter R, Bartlett J, Fireman B, Lewis E, Klein NP. . Pediatrics. 2017;139(5):pii:e20164091.
Boulet SL, Chamberlain AT, Biswas HH, Jamieson DJ. . JAMA. 2019;322(21):2134–6.
Clarice Paiva Santana, Karin Regina Luhm, Silvia Emiko Shimakura. . Vaccine. 2021;39(6):976–83.
Dabrera G, Amirthalingam G, Andrews N, et al. . Clin Infect Dis. 2015;60(3):333–7.
DeSilva M, Vazquez-Benitez G, Nordin JD, et al. . Vaccine. 2017;35(29):3655–60.
Fernandes EG, Sato APS, Vaz-de-Lima LRA, et al. . Vaccine. 2019;37(36):5481-5484.
Friedrich F, Valadão MC, Brum M, et al. . PLoS One. 2020;15(1):e0228022.
Kim G, Berry JG, Janes JL, Perez A, Hall M. . Hosp Pediatr. 2022;12(3):e106-e9.
Langsam D, Anis E, Haas EJ, et al. . Vaccine. 2020;38(12):2700-6.
Regan AK, Moore HC, Binks MJ, et al. . Pediatrics. 2023;152(5):e2023062664.
Saul N, Wang K, Bag S, et al. . Vaccine. 2018;36(14):1887–92.
Skoff TH, Blain AE, Watt J, et al. . Clin Infect Dis. 2017;65(12):1977–83.
Skoff TH, Deng L, Bozio C, Hariri S. . JAMA Peds. 2023;177(4):395–400.
Sukumaran L, McCarthy NL, Kharbanda EO, et al. . Pediatrics. 2018;141(3):e20173310.
Vizzotti C, Juarez MV, Bergel E, et al. . Vaccine. 2016;34(50):6223–8.
Vygen-Bonnet S, Hellenbrand W, Garbe E, et al. . BMC Infect Dis. 2020;20(1):136.
Winter K, Cherry JD, Harriman K. . Clin Infect Dis. 2016;64(1):9–14.
Winter K, Cherry JD, Harriman K. . Clin Infect Dis. 2016;64(1):3–8.
Safety
DeSilva M, Vazquez-Benitez G, Nordin JD, et al. JAMA. 2016;316(17):1823–5.
Florea A, Sy LS, Ackerson BK, et al. . Infect Dis Ther. 2023;12(2):411–23.
Greenberg V, Vazquez-Benitez G, Kharbanda EO, et al. Vaccine. 2023;41(22):3429–35.
Immink MM, Kemmeren JM, Broeders L, et al. . Vaccine. 2023 Jan 3:S0264-410X(22)01596-1.
Kerr SM, Van Bennekom CM, Mitchell AA. . Birth Defects Res. 2020;112(5):393–403.
Kharbanda EO, Vazquez-Benitez G, Lipkind HS, et al. . JAMA. 2014;312(18):1897–1904.
Kharbanda EO, Vazquez-Benitez G, Lipkind H, et al. . Prev Med. 2014;67:316–9.
Kuznetsova A, Ceregido MA, Jourquin A, Campora L, Da Silva FT. . Vaccine. 2022;40(6):904–11.
Laverty M, Crowcroft N, Bolotin S, et al. . Pediatrics. 2021;147(5):e2020042507.
Liang J. Overview of Tdap use during pregnancy: Unpublished and recent data presented to the Advisory Committee on Immunization Practices (ACIP), Atlanta, GA; February 23, 2011.
McMillan M, Clarke M, Parrella A, Fell DB, Amirthalingam G, Marshall HS. . Obstet Gynecol. 2017;129(3):560–73.
Mohammed H, Roberts CT, Grzeskowiak LE, et al. . Vaccine. 2021;39(2):324–31.
Morgan JL, Baggari SR, McIntire DD, Sheffield JS. . Obstet Gynecol. 2015;125(6):1433–8.
Moro P. Safety of Tdap vaccine during pregnancy: Enhanced surveillance in VAERS presented to the Advisory Committee on Immunization Practices (ACIP), Atlanta, GA; February 26, 2014.
Munoz FM, Bond NH, Maccato M, et al. . JAMA. 2014;311(17):1760–9.
Panagiotakopoulos L, McCarthy NL, Tepper NK, et al. . Obstet Gynecol. 2020;136(6):1086–94.
Rasmussen S. Safety of maternal Tdap vaccination for mother and fetus presented to the Advisory Committee on Immunization Practices (ACIP), Atlanta, GA; June 22, 2011.
Shakib JH, Korgenski K, Sheng X, Varner MW, Pavia AT, Byington CL. . J Pediat. 2013;163(5):1422–26.
Sukumaran L, McCarthy NL, Kharbanda EO, et al. . JAMA. 2015;314(15):1581–7.
Sukumaran L, McCarthy NL, Kharbanda EO, et al. . Obstet Gynecol. 2015;126(5):1069–74.
Tseng HF, Sy LS, Ackerson BK, et al. Vaccine. 2022;40(32):4503–12.
Zheteyeva YA, Moro PL, Tepper NK, et al. . Am J Obstet Gynecol. 2012;207(1):59.e1–7.
Infection sources and cocooning
Infection sources
Bisgard KM, Pascual FB, Ehresmann KR, et al. Pediatr Infect Dis J. 2004;23:985–89.
Skoff TH, Kenyon C, Cocoros N, et al. . Pediatrics. 2015;136(4):635–41.
Wendelboe AM, Njamkepo E, Bourillon A, et al. . Pediatr Infect Dis J. 2007;26:293–99.
Cocooning
Blain AE, Lewis M, Banerjee E, et al. . Clin Infect Dis. 2016;63(suppl 4):S221–6.
Healy CM, Rench MA, Wootton SH, Castagnini LA. . Pediatr Infect Dis J. 2015;34(1):22–6.
Resources
ACIP recommendations
Use of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccines: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2019. MMWR. 2020;69(3):77–83.
Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2018;67(RR-2):1–44.