TY  - JOUR
AU  - Kompaniyets, Lyudmyla
AU  - Pennington, Audrey F.
AU  - Goodman, Alyson B.
AU  - Rosenblum, Hannah G.
AU  - Belay, Brook
AU  - Ko, Jean Y.
AU  - Chevinsky, Jennifer R.
AU  - Schieber, Lyna Z.
AU  - Summers, April D.
AU  - Lavery, Amy M.
AU  - Preston, Leigh Ellyn
AU  - Danielson, Melissa L.
AU  - Cui, Zhaohui
AU  - Namulanda, Gonza
AU  - Yusuf, Hussain
AU  - Mac Kenzie, William R.
AU  - Wong, Karen K.
AU  - Baggs, James
AU  - Boehmer, Tegan K.
AU  - Gundlapalli, Adi V.
PY  - 2021
TI  - Underlying Medical Conditions and Severe Illness Among 540,667 Adults Hospitalized With COVID-19, March 2020-March 2021
T2  - Preventing Chronic Disease
JO  - Prev Chronic Dis
SP  - E66
VL  - 18
CY  - Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
N2  - INTRODUCTION  Severe COVID-19 illness in adults has been linked to underlying medical conditions. This study identified frequent underlying conditions and their attributable risk of severe COVID-19 illness. METHODS  We used data from more than 800 US hospitals in the Premier Healthcare Database Special COVID-19 Release (PHD-SR) to describe hospitalized patients aged 18 years or older with COVID-19 from March 2020 through March 2021. We used multivariable generalized linear models to estimate adjusted risk of intensive care unit admission, invasive mechanical ventilation, and death associated with frequent conditions and total number of conditions. RESULTS  Among 4,899,447 hospitalized adults in PHD-SR, 540,667 (11.0%) were patients with COVID-19, of whom 94.9% had at least 1 underlying medical condition. Essential hypertension (50.4%), disorders of lipid metabolism (49.4%), and obesity (33.0%) were the most common. The strongest risk factors for death were obesity (adjusted risk ratio [aRR] = 1.30; 95% CI, 1.27-1.33), anxiety and fear-related disorders (aRR = 1.28; 95% CI, 1.25-1.31), and diabetes with complication (aRR = 1.26; 95% CI, 1.24-1.28), as well as the total number of conditions, with aRRs of death ranging from 1.53 (95% CI, 1.41-1.67) for patients with 1 condition to 3.82 (95% CI, 3.45-4.23) for patients with more than 10 conditions (compared with patients with no conditions). CONCLUSION  Certain underlying conditions and the number of conditions were associated with severe COVID-19 illness. Hypertension and disorders of lipid metabolism were the most frequent, whereas obesity, diabetes with complication, and anxiety disorders were the strongest risk factors for severe COVID-19 illness. Careful evaluation and management of underlying conditions among patients with COVID-19 can help stratify risk for severe illness.
SN  - 1545-1151
UR  - https://doi.org/10.5888/pcd18.210123
DO  - 10.5888/pcd18.210123
ER  -