2021 Project: Arizona State University

SARS-CoV-2 genomic surveillance in Arizona

What to know

Arizona State University conducted next-generation sequencing and developed tools to track SARS-CoV-2 in Arizona. Awarded in 2021, this project sequenced 2,000 positive samples over 12 months. Sample criteria included reinfection cases, routine surveillance of low-population counties, and vaccinated individuals. The university developed a tool for researchers to upload sequences and analyze the data for emerging variant trends.

Decorative image with words "2021" and "SARS-CoV-2"

Findings on SARS-CoV-2 surveillance and investigations

  • This project contributed sequencing data to SARS-CoV-2 baseline surveillance in Arizona.12

Findings on SARS-CoV-2 variant characteristics

This project:

  • Used software developed to analyze the spike protein of SARS-CoV-2 to analyze mutations in the vaccine antigenic site of respiratory syncytial virus (RSV).3
  • Contributed sequencing data to characterization of SARS-CoV-2 illness due to the BA.2 variant in a university-associated cohort.4
  • Contributed sequencing data to characterization of SARS-CoV-2 mutations that reduce diagnostic assay detection.5

New and improved sequencing software tools

This project developed a mutation analysis tool to analyze large sequencing datasets with code publicly available and adapted the mutation analysis tool to identify mutations in RSV F protein involved in vaccine immunity.

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Content Source:
National Center for Emerging and Zoonotic Infectious Diseases (NCEZID)
  1. . mBio, 2023
  2. . medRxiv, 2024
  4. . Emerging Infectious Diseases, 2022.
  5. . Viruses, 2022.